Interestingly, we found that genetic inhibition of STING attenuates diabetes-induced phosphorylation of TBK1, IKK, IκB, and NF-κB, which is associated with reduced iNOS and ICAM-1 expression along with decreased superoxide production and leukostasis in STING-perturbed diabetic mice. Here, TBK1 is linked to diabetes mellitus.