Treating Mdr2–/– animals with CM-101 (D8) resulted in a reduction of liver fibrosis, which was moderate in the animals treated with the 5 mg/kg dose (data not shown) and significant in animals treated with the 10 mg/kg dose of CM-101 (D8), with a 30% decrease in SR staining and reduction in bridging fibrosis (Figure 3, B and C). Here, ABCB4 is linked to Hepatic fibrosis.