Hepatic NETs form liver‐specific premetastatic niches (PMNs) that promote liver metastasis through the capture of CTCs by NETs and the chemotaxis of CTCs by NET‐DNA.[18] To investigate whether FGF19‐induced NETosis occurred prior to the colonization of metastatic CRC cells in the liver, we established an in vivo liver metastatic model with splenic injection of FGF19‐expressing KM12SM cells treated with or without FGF19 neutralizing antibody and obtained liver tissue and peripheral blood samples from mice on specific days after the injection. The gene discussed is FGF19; the disease is colorectal carcinoma.