Given that iCAFs secrete abundant cytokines and inflammatory factors, we mainly examined the changes in stromal components of various immune cell populations, including neutrophils, macrophages, natural killer (NK) cells, B cells, and dendritic (DC) cells, in liver metastases caused by FGF19‐overexpressing or ‐knockdown CRC cells. The gene discussed is FGF19; the disease is colorectal carcinoma.