Gene expression profiles indicated that compared with biCEBPA/‐like IKZF1, the HOXA/B, HSPC expression signature, proto‐oncogene pathways including VEGF, B‐cell receptor, NOTCH, MAPK, WNT, TGF‐beta, Rap1 signalling pathways were significantly upregulated in the IKZF1 N159S‐positive AML. Here, IKZF1 is linked to acute myeloid leukemia.