In line with our previous work,14IKZF1 N159S was associated with myelodysplasia‐related changes, which frequently coexisted with RUNX1 and spliceosome mutations, and was characterised by the upregulation of haematopoietic stem progenitor cell signature (HSPC) and core markers including HOXA/B, MYCT1, PAWR and BEND4.14 This evidence concerns the gene RUNX1 and Myelodysplasia.