A protein interaction network was constructed to integrate and visualise these screened downstream factors of IKZF1 N159S (Figure S6), functional enrichment analysis indicated that the interacting proteins were significantly enriched in pathways related to cancer development, that is, P53 signalling pathways, and were also enriched in the cell cycle regulation‐related pathways, consistent with our previous function assays (Figure 5D). This evidence concerns the gene TP53 and cancer.