To evaluate the prognostic value of IKZF1 mutations under other concomitant factors, we constructed a multivariable Cox regression model incorporating age as well as IKZF1, CEBPA and RUNX1 mutations, and identified that mutant IKZF1, rather than RUNX1, could be an independent predictive factor for OS in AML patients (Figure S3C). The gene discussed is RUNX1; the disease is acute myeloid leukemia.