Gene expression profiles indicated that compared with biCEBPA/‐like IKZF1, the HOXA/B, HSPC expression signature, proto‐oncogene pathways including VEGF, B‐cell receptor, NOTCH, MAPK, WNT, TGF‐beta, Rap1 signalling pathways were significantly upregulated in the IKZF1 N159S‐positive AML. This evidence concerns the gene VEGFA and acute myeloid leukemia.