IKZF1 and acute lymphoblastic leukemia: Two most frequent point mutations in our cohort including IKZF1 N159S and G158S were chosen for further investigation, and IKZF1 N159Y was also selected as a positive control, which was extensively reported to affect the initiation and development of ALL and disturb the normal function of wild‐type (WT) IKAROS.32, 33