To confirm that p16 has a role in HFD‐induced lung fibrosis, 12‐month‐old WT and ApoE−/− mice were fed a HFD diet and administered with ABT263 for 6 months, while 12‐month‐old p16−/− and ApoE−/−p16−/− mice were fed a HFD without ABT263 treatment. The gene discussed is CDKN2A; the disease is pulmonary fibrosis.