CD4 and HIV infectious disease: Similar results were also observed in env-pseudotyped, single-cycle HIV infection of IL-4-treated resting CD4 T cells [95]; while the percentages of GPF+ cells (measurement of Nef) were comparable with or without integration (12% versus 7.2%), only low-expression GFP+ dim cells but not high-expression GFP+ bright cells were generated when integration was inhibited (GPF+ bright cells: 7.4% with integration versus 0.2% without integration).