RB1 and cancer: Furthermore, since p21 is dysregulated in some tumors [35], it could be interesting to further investigate the action of dex on the multicomplex protein assembly Lamin A/C, HDAC2, LAP2α, pRb, E2F1, and FoxO3a on the CDKN1A promoter that might regulate p21 expression, in some cancer cell types.