To elucidate the relationship between Nectin-4 and EC risk factors, including genetic factors, we analyzed MMR deficiency-related genes (MLH1, MSH2, MSH6, and PMS2), p53, p16, hormone receptor status, and lymphovascular space invasion (LVSI). This evidence concerns the gene NR4A1 and hyperinsulinemic hypoglycemia, familial, 4.