FH and cancer: For example, strong evidence exists that some mutations in TCA cycle enzymes, such as succinate dehydrogenase (SDH) and fumarate hydratase (FH), are associated to and impaired oxidative phosphorylation that highly contributes to the metabolic reprogramming observed in cancer cells [45,46,47,48,49], as well as with an increased hypoxia-inducible factor (HIF-1α)-mediated glucose uptake and glycolysis [50,51,52].