SIRT3 and cancer: However, its role in other types of cancer, where the oxidative phosphorylation is still the most important source of energy supply, needs to be clarified, as SIRT3 promotes oxidative phosphorylation and inhibits glycolysis [166], and some recent studies demonstrated that SIRT3 can exert a pro-tumoral role depending on the metabolic circumstances of the tumor [169,170,171].