SLC2A1 and neoplasm: For instance, the highly cancer-related pathway PI3K-Akt-mTOR induces an enhanced glucose capture, modulating GLUT1 expression and activating phosphofructokinase (PFK) and hexokinase (HK), among other enzymes, which contribute to high availability of glucose for the tumor cells, thus feeding the high needs of the Warburg metabolism [30].