Thanks to its capacity to control succinate accumulation, to hinder cancer metabolic changes [166], and its role regulating the acetylation of several mitochondrial proteins including superoxide dismutase II, which in turn reduces the amount of ROS in the mitochondria [167], SIRT3 has been described as a tumor suppressor in glycolysis-dependent cancers [166,168]. This evidence concerns the gene SIRT3 and cancer.