BRAF and melanoma: However, COMBI-i, a phase III trial, showed that combining spartalizumab (PD-1 inhibitor) and the BRAF-MEK inhibitor (dabrafenib and trametinib) for BRAFV600-mutant advanced melanoma patients induced modest improvement of mPFS than the BRAF-MEK inhibitor group (16.2 months vs. 12 months), but there were high rates of grade 3 adverse events (55% vs. 33%) [96].