Immune cells found in the glioma TME include macrophages, neutrophils, dendritic cells (DCs), and natural killer (NK) cells of the innate immune system; CD4+ T cells, CD8+ T cells, and B cells of the adaptive immune system; and immunosuppressive cells such as monocyte-derived suppressor cells (MDSCs) and regulatory T cells (Treg). This evidence concerns the gene CD8A and central nervous system cancer.