In vivo, melanoma cells secrete a plethora of pro-angiogenic factors, including VEGF, basic fibroblast growth factor (bFGF or FGF-2), interleukin-8 (IL-8), placental growth factor (PlGF), and platelet-derived growth factor (PDGF) [11]. The gene discussed is CXCL8; the disease is melanoma.