CSF1 and melanoma: Indeed, consistent with previous studies reporting elevated levels of the immune suppressive factors IL-10 [49,50,51] and M-CSF [52] in the blood of advanced melanoma patients, and similar to what we previously reported for SK-MEL-28-RhS [15], upregulated secretion of IL-10 and M-CSF was also found in A375-RhS-derived culture supernatants.