TGFB1 and neoplasm: In vivo, IL-10, M-CSF, and TGFβ are all involved in the polarization and accumulation at the tumor site of tumor-associated macrophages (TAMs), which display features of alternatively activated M2 macrophages [42,43] and contribute to the suppression of anti-cancer T-cell-mediated immune responses [6,44,45,46].