As shown in Figure 2, the A375-RhS, which displayed the most invasive tumor phenotype, exhibited an increased release of the pro-inflammatory chemokines and cytokines CCL2 (4-fold increase), GM-CSF (3-fold increase), IL-6 (7-fold increase), and IL-8 (9-fold increase) and of the anti-inflammatory cytokines IL-10 (229-fold increase), M-CSF (1.8-fold increase), and TGFβ (1.3-fold increase), when compared to the control RhS (Figure 2b). This evidence concerns the gene IL10 and neoplasm.