IDH1 and neoplasm: The median S/N of these two shorter-chain CL species was compared for viable tumor regions of IDH1 mutant specimens and found to be detected at significantly lower abundance in IDH1 mutant tissues versus IDH1 wild-type tissues (Wilcoxon, P = 0.0275 for m/z 723.480 (CL(72:8)) and P = 0.0275 m/z 724.483 (CL(72:7)), Figure S5B,C).