The observed decreases in mRNA expression levels of ETC-related enzymes MT-ATP6 and 8 and MT-CO1-3 in GBM versus lower-grade AST, while other genes encoding mitochondrial trans-membrane enzymes were not found to be differently expressed among these tumors, warrant further characterization of both gene expression and enzyme levels in these tumors to understand how decreased diversity of longer chain CL species impacts tumor growth and progression. The gene discussed is MT-ATP6; the disease is neoplasm.