CRLS1 and brain neoplasm: We considered only human primary brain tumors with AST 2 (A2, N = 131), AST 3 (A3, N = 120), and GBM (N = 225) histologies for 9 enzyme encoding-genes: TOMM20; MT-CO1, MT-CO2, and MT-CO3, encoding cytochrome c oxidase subunits; MT-ATP6, MT-ATP8, encoding ATP synthase subunits; TIMM22 encoding an inner mitochondrial membrane translocase; and CRLS1, which catalyzes CL synthesis.