TP53 and cancer: Through in vivo and in-cell cultures, a recurrence of genetic events in workers exposed to chromium VI was also showed, such as the loss of MLH1 expression, p16INK4A methylation, and a low percentage of p53 mutations [104] also on urothelial cell lines, thus reinforcing the possible role of chromium in different cancers, such as LC and bladder cancer [102,105].