Several Pt and Pd complexes, namely Pt(II) complex 40 [150] with a thiocarbohydrazone ligand and Pd(II) complex 41 [151] with a bis-imidazolium-based N,N′-bis-(salicylidene)-R,R-1,2-diaminocyclohexane ligand, were reported to significantly upregulate the p53 expression in various cancer cell lines; however, the dependence of the mechanism of action on the p53 has not been investigated. Here, TP53 is linked to cancer.