During glioma stem-cell (GSC) differentiation, AGO1 facilitates the binding of miR-145-5p to interleukin enhancer-binding factor 3 (ILF3), a double-stranded RNA-binding protein, and fat mass and obesity-associated protein (FTO), an RNA N6-methyladenosine (m6A) demethylase. The gene discussed is ILF3; the disease is glioma.