Another example includes the epigenetic silencing of miR-139 (miR-139-3p and miR-139-5p) by PRC2-mediated hypermethylation, which frequently occurs in mixed-lineage leukemia (MLL)–AF9 fusion protein-expressing acute myeloid leukemia (AML) [25]. Here, KMT2A is linked to acute myeloid leukemia.