M6A readers recognize and interact with m6A-modified RN7SK, which facilitates the formation of RN7SK secondary structures and stabilizes its expression. RN7SK prevents the mRNA degradation of m6A readers by exonucleases, increasing their expression. The upregulation of m6A readers such as EWSR1 and KHDRBS1 promotes Wnt/β-catenin signaling and tumorigenesis by suppressing ubiquitin protein Cullin1 in various tumor types. The gene discussed is EWSR1; the disease is neoplasm.