sdnRNA-3 promotes the enrichment of chromodomain-helicase-DNA-binding protein 4 (CHD4), also known as Mi-2β, to the Nos2 promoter. This induces H3K27me3 modification of the Nos2 gene and represses the transcription of its gene product, inducible nitric oxide synthase (iNOS). The decrease in sdnRNA-3 expression in TAMs increases iNOS transcription and inhibits tumor growth. The gene discussed is CHD4; the disease is neoplasm.