Moreover, the expression of CD8 effector and CD4 mature genes was significantly and positively associated with the gene expression of CXCL9, CXCL10, CXCL11, and CCL5 in pMMR/MSS CRC, suggesting that the production of CXCL9/10/11 and CCL5 might contribute to the infiltration of CD8+ T cells and CD4+ T cells in pMMR/MSS CRC (Figure 3G,H). Here, CD4 is linked to colorectal carcinoma.