No correlation was observed between cGAS and STING expression in tumor cells in pMMR/MSS CRC as determined through IHC analysis of our cohort and the gene expression analyses of public datasets from TCGA and GEO, suggesting that different regulatory mechanisms for the expression of cGAS and STING in tumor cells might exist in pMMR/MSS CRCs. Here, CGAS is linked to colorectal carcinoma.