In this study, we examine the expression level of tumor cell-intrinsic cGAS-STING and its association with the infiltration of CD8+ T cells and clinical outcomes in pMMR/MSS CRC by analyzing immunohistochemistry (IHC) of our cohort and gene expression datasets obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). This evidence concerns the gene CD8A and colorectal carcinoma.