In contrast, in dMMR CRC, cGAS−/STING− CRC cases were observed in only 20% of all dMMR CRCs (Figure S3A), and 52.5% of dMMR CRC lacked cGAS expression, while 40.0% lacked STING expression in tumor cells (Figure S3B). Here, STING1 is linked to colorectal carcinoma.