Upon dividing pMMR/MSS CRC cases into cGAS-high or cGAS-low and STING-high or STING-low groups, the expression of CD8 effector and CD4 mature gene signatures was markedly higher in cGAS-high and STING-high pMMR/MSS CRCs than in cGAS-low and STING-low pMMR/MSS CRCs, respectively (Figure 3C,D), suggesting that the infiltration of CD8+ effector T cells and CD4+ mature T cells might be associated with the expression of cGAS and STING in pMMR/MSS CRCs. Here, CD8A is linked to colorectal carcinoma.