CGAS and colorectal carcinoma: We observed four distinct expression patterns of cGAS-STING in CRC tumor cells, which included cases that expressed both cGAS and STING (cGAS+/STING+), those that expressed cGAS only (cGAS+/STING−), those that expressed STING only (cGAS−/STING+), and those that lacked expressions of both cGAS and STING (cGAS−/STING−) (Figure 1C).