Interestingly, we found that tumor cell-intrinsic expression of STING, but not cGAS, was decreased in the advanced stages of pMMR CRC (Figure 2A,B and Figure S6), and the percentages of cases lacking cGAS-STING expression in tumor cells increased in stages II and IV of pMMR CRC (Figure 2C). This evidence concerns the gene CGAS and neoplasm.