Thus, in this study, we aimed to: (1) develop an animal model to investigate the dose–response relationship between cochlear irradiation and HL, (2) understand potential molecular and cellular mechanisms involved in radiation injury to the cochlea, and (3) test the effect of single fraction versus hypofractionated radiation on the specificity and viability of normal Schwann cells (SC) and merlin-deficient Schwann cells (MD-SC; aka tumor cells). This evidence concerns the gene NF2 and neoplasm.