LCK and acute lymphoblastic leukemia: For example, pharmacological inhibitors such as dasatinib, nintedanib, WH-4-023 and bosutinib or specific Lck gene silencing, were shown to induce cell death in GC-resistant ALL cells, and combined treatment with GCs is able to reverse GC resistance in vitro, ex vivo, in vivo and in PDX samples [2,43,45,46,47].