BICRA and central nervous system cancer: As mentioned above, the two genes, which are located directly adjacent to one another on chromosome 19q, are co-deleted in 1p/19q co-deleted low-grade gliomas and also frequently in prostate adenocarcinomas (~10–12% of cases) [72], suggesting that the dual loss of CIC and ERF (possibly with BICRA/GLTSCR1, as discussed above) may favour tumour development, possibly through their combined dysregulation of MAPK signalling.