Notably, we also identified BECN1 as being both co-essential with and a SL interactor of CIC (Supplementary Table S4), indicating that CIC likely plays a synergistic role either serially or in parallel with BECN1, and that the combined inactivation of these two genes, at least in the HCC-366 (NSCLC) and JHUEM1 (endometrial carcinoma) cell lines, may not be compatible with cell survival. Here, BECN1 is linked to hepatocellular carcinoma.