CIC and cancer: Capicua (CIC) is a transcriptional repressor that is impacted by somatic mutations or rearrangements in several cancer types, including undifferentiated small round cell sarcomas (~60% of cases) [1], oligodendrogliomas (~50–80%) [2,3], gastric adenocarcinomas (~9%) [4], endometrial carcinomas (~7%) [5], and melanomas (~8%) [6,7].