Rescue-of-expression experiments consisting of the treatment of representative cancer cell lines with 5-aza-2′-deoxycytidine, which inhibits DNA methylation, combined or not with trichostatin A, which is an inhibitor of DNA deacetylation, provided additional evidence of hypermethylation being the main cause of MAL gene expression suppression in distinct cancers [67,70,71,78,80,81,87,122,125,129]. The gene discussed is MAL; the disease is cancer.