It is interesting, though puzzling, that the same study shows that tumor growth in immunocompromised nude mice was not significantly different among control cancer cells or the same cells with MAL2 overexpressed or downmodulated, whereas MAL2-overexpressing cells and MAL2-KD cells produced tumors with significantly higher and lower, respectively, volume and weight compared to those of control cells when the same assay was performed in immunocompetent mice [146]. The gene discussed is MAL2; the disease is neoplasm.