Astragaloside IV inhibits HCC progression by modulating macrophage polarization, and Min et al. showed that Astragaloside IV through the downregulation of the TLR4/NF-κB/STAT3 signaling pathway stimulates the aggregation of M1 macrophages and hinders M2 macrophages in vitro and in vivo [148]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.