In particular, the TLR4/E2F transcription factor 1 (E2F1)/NANOG signaling maintains the tumor-initiating stem-like cell (TICs) phenotype, enhancing the expression of fatty acid oxidation (FAO) genes and downregulating the expression of genes associated with mitochondrial oxidative phosphorylation (OXPHOS) and ROS formation. The gene discussed is E2F1; the disease is neoplasm.