Yin et al. demonstrated that β-catenin is a downstream molecule of the TLR4 signaling pathway in HBV-derived HCC models, while the inhibition of TLR4/β-catenin signaling hindered the invasion capacity of HepG2.2.15, MHCC97-H, and Hep3B cells in vitro and downregulated metastatic tumor growth in vivo [70]. Here, TLR4 is linked to hepatocellular carcinoma.