CTLA4 and hepatocellular carcinoma: Several ICI combinations have shown promising results in the treatment of HCC, including nivolumab (anti-PD-1) plus ipilimumab (anti-CTLA-4), pembrolizumab (anti-PD-1) plus lenvatinib (TKI), which did not manage to outperform lenvatinib in OS and progression-free survival (PFS), and atezolizumab plus bevacizumab, which improved PFS and OS in clinical trials and comprise the mainstay of HCC treatment [156].