CD163 and neoplasm: M2-like macrophages, which are characterized by the expression of markers CD163 and CD206, have been shown to promote tumor growth and metastasis by producing growth factors and cytokines that stimulate angiogenesis and immunosuppression; M1-like macrophages, on the other hand, which are characterized by the expression of markers CD86 and HLA-DR, have been shown to exhibit anti-tumor activity by producing cytokines that activate T cells and induce tumor cell apoptosis.