The myf5:GFP+/mylz2:mCherry-negative (G+R-) stem cell-like tumor-propagating-cell (TPC) population has been shown to have self-renewal capacity, while late-differentiating myf5:GFP-negative/mylz2:mCherry+ tumor cells (G-R+) lack the capacity to self-renew [17,18]. This evidence concerns the gene MYF5 and neoplasm.