To our best knowledge, this is the first investigation to evaluate the physiologic [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 uptake in ganglia in patients with prostate cancer with respect to its underlying molecular and physical mechanisms on an intra-individual basis using the same PET/CT scanner in a monocentric, retrospective design. Here, FOLH1 is linked to Familial prostate cancer.