POMC and panhypopituitarism: Panhypopituitarism, characterised here as simultaneous deficiencies across GH, gonadotrophins, ACTH and TSH, was present in 52 patients prior to surgery (13.6% of the total population; 15.8% of known endocrine profiles), and rose to 55 patients in the period immediately following surgery (14.4% of the population).