Indeed, PD-L1 expression could be quantified in the tumor cells (TC) solely leading to a “tumor proportion score” (TPS) expressed in terms of percentage of PD-L1-positive TC (with complete or incomplete membranous staining of any intensity) or in association with the expression by mononuclear immune cells (IC) except plasma cells (i.e., lymphocytes and monocytes–macrophages, with membranous and/or cytoplasmic IHC staining) through a “combined positive score” (CPS). This evidence concerns the gene CD274 and neoplasm.