RAC1 and oral cavity squamous cell carcinoma: In addition, Xiao et al. demonstrated that RES can inhibit the malignant progression of CAL-27 oral squamous cell carcinoma cells by down-regulating the expression of vascular endothelial growth factor (VEGF), RGS5, CD105, and cell adhesion molecules ITGA5, ITGB1, and CD44 via the zinc finger protein 750/Ras-related C3 botulinum toxin substrate 1 (ZNF750/RAC1) signaling pathway, leading to a reduction in vascular normalization, metastasis, adhesion, and migration of CAL-27 cells [74].