Our first-in-human melanoma imaging work using 68Ga-DOTA-GGNle-CycMSHhex clearly detected human metastatic melanoma lesions in the brain, lung, connective tissue, and intestines [10], demonstrating the clinical relevance of MC1R for melanoma imaging, as well as for potential MC1R-targeted radionuclide therapy. The gene discussed is MC1R; the disease is melanoma.