PD-L1 staining may be observed on both infiltrating immune cells and tumor cells, and an abundance of type-I and type-II interferons, IL-12, IL-23, IL-1β, TNFα, IL-2, granzymes, CXCL9, CXCL10, and other pro-inflammatory/effector cytokines may also be observed [95]. This evidence concerns the gene TNF and neoplasm.