TLS present similarities with lymph nodes; high TLS densities in CRC, especially within MSI tumors [115], along with the up-regulation of genes in the HLA I and II gene family and those connected to antigen processing and presentation, such as TAP1, TAP2, and β2-microglobulin, intimate strong anti-tumor immunity in the tumor microenvironment of the CMS1 category [61]. This evidence concerns the gene TAP1 and neoplasm.