Furthermore, when the E0771 cells (1 × 106) were injected into the mammary fat pads of the mice, spontaneous lung metastasis was significantly reduced in CD11b−/− mice (n = 5, p < 0.05), but there was no significant difference in primary tumor growth between WT or CD11b−/− C57BL/6 mice (Figure 2D,E). Here, ITGAM is linked to neoplasm.