SPHK1 and pachyonychia congenita: Resveratrol and epigallocatechin-3-gallate or a mixture of polyphenols from grapevine extract (Vineatrol, 47.5% of resveratrol) or from green tea (polyphenol E, 62% of epigallocatechin-3-gallate) decreased proliferation and cell viability by blocking ERK/Phospholipase D/SK1 pathway in PC-3 and C4-2B cells (a castration-resistant PC cell line isolated from the bone metastasis of a mouse xenograft inoculated with C4-2 cells, a subline of LNCaP) [74].