ABC294640 notably reduced AR and Myc expression, two oncogenes directing PC tumorigenesis in LNCaP, C4-2, and 22Rv1 cells (a human PC cell line obtained from a xenograft gradually spread in mice after castration-induced regression and relapse of the parental androgen-dependent CWR22 xenograft) [76]. This evidence concerns the gene AR and pachyonychia congenita.