Authors demonstrated a significant reduction in tumor growth after treatment with anti-S1P antibody (25 mg/Kg, every 3 days, i.p.)for 28 days in orthotopic models of breast cancer (MDA MB-231, MDA-MB-468), ovarian cancer (SKOV3) and in an s.c. model of lung adenocarcinoma (A-549) [157]. The gene discussed is MBTPS1; the disease is neoplasm.