In line with this observation, our group was able to demonstrate, through sequential monitoring of IFNγ-producing NPM1mut-specific T cells coupled with molecular MRD [32,33,34], that the kinetics of leukemia-specific T cells inversely correlated with molecular or morphologic leukemia status, having detected increased and sustained specific immune responses in patients with persistent molecular CR, in some cases years after completion of leukemia treatments [16]. Here, IFNG is linked to leukemia.