NPM1 and acute myeloid leukemia: Thence, an NPM1mut-targeted treatment, based on the use of a patient-derived somatic advanced therapy medicinal product (ATMP) delivered upon the finding of MRD or hematologic relapse after conventional or low-toxicity therapy, may help promote (re)induction of remission in patients with NPM1-mutated AML not amenable to HSCT, and contribute to obtain pre-transplant MRD negativity in candidates for allo-HSCT [17].