Van der Lee et al. have been able to clone and transfer a NPM1-mutated, HLA-A2-restricted, T cell receptor with efficient in vitro specificity against NPM1-mutated primary leukemic blasts and in vivo activity in immunodeficient mice engrafted with a human NPM1-mutated AML cell line [10]. Here, NPM1 is linked to acute myeloid leukemia.