CD80 and hepatocellular carcinoma: Similarly, Dong et al. evaluated TAM as a predictive marker for HCC prognosis and found the increased level of CD206+ M2 macrophages and decreased level of CD80+ M1 macrophages promoted HCC to an aggressive phenotype with poor overall survival (p = 0.027 and p = 0.024, respectively) and increased time to recurrence (p = 0.037 and p = 0.031, respectively).