Similarly, Ye et al. compared gene expression data of HCC patients and normal tissue samples and selected differentially expressed immune related genes in HCC samples, and constructed an immune-related gene signature based on eight genes such as CHGA, RAETIE, FGF9, GIP, NROB1, IL20RA, ESRRG, and GNNRH2 to predict the HCC prognosis [127]. The gene discussed is ESRRG; the disease is hepatocellular carcinoma.