Similarly, the interaction between the programmed cell death protein 1 (PD-1) receptor expressed on the surface of T cells and programmed cell death ligand 1 (PD-L1) expressed on the surface of APCs, tumor cells, and other cells will lead to the suppression of T-cell responses and will promote the formation of regulatory T cells (T regs) [32]. The gene discussed is CD274; the disease is neoplasm.