ITGAE and non-small cell lung carcinoma: As is revealed by transcriptional analysis of tumor cells and in vitro DC migration assays in a mouse model of NSCLC with BRAF V600E mutation and PTEN-deficiency, reduction in chemokine CC motif ligand4 (Ccl4) production, which is deemed to be an efficient chemoattractant for multiple kinds of myeloid cells, including CD103+ DCs, could explain the undesirable infiltration of CD8+ T cells into TIME induced by the declined recruitment of CD103+ DCs.