It has been proven that modification of tumor-stromal interactions performs an indispensable role in promoting temporal TMH where extracellular matrix (ECM) remodeled (termed as desmoplastic stroma) with the cleavage of adhesion proteins, such as integrins and cadherin, which can regulate migration and attachment of cancer cells and with the processing of intercellular junction proteins (desmoglein (Dsg)/desmocollin (Dsc)) which can control tumor cohesion and with the alteration of intercellular signaling. The gene discussed is DSG1; the disease is neoplasm.