There are no statistically significant associations observed in the overall analysis for either MDM2 or MDM4 gene variants in models that included the covariates: age at diagnosis of the first primary, sex, study center, presence of multiple primary melanomas, and time-dependent crossover status for patients who entered the study with single primary melanoma and developed a subsequent melanoma during follow-up, anatomic site, and logged Breslow thickness of the deepest primary melanoma. This evidence concerns the gene MDM4 and melanoma.