BCL2 and cancer: For example, overexpression of the anti-apoptotic members of the Bcl-2 family, such as Bcl-2 and BCL2-like 1 (Bcl-XL) (intrinsic apoptotic pathway), have been linked to cancer chemoresistance, while elevated levels of pro-apoptotic proteins, such as BCL2 associated X (Bax), promote apoptosis and sensitize tumor cells to various cancer treatments [125,126].