In EEC, DNA methyltransferase 3B (DNMT3B) overexpression occurs more often in the subgroups with miR-145 and miR-143 downregulation, and there is a significant correlation between DNMT3B and miR-145 status (p = 0.021); this correlation is not significant in non-EEC (p ≥ 0.05). The gene discussed is DNMT3B; the disease is exstrophy-epispadias complex.