In a study about transforming growth factor (TGF) β1 (TGF-β1) signaling in liver cancer, Sohn and colleagues proposed that tristetraprolin (TTP) promoter hypermethylation contributes to TGF-β1 deregulation in the malignant progression of hepatocellular carcinoma [126]. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.