Thus, the protective effect of the MUC1 barrier and the de-protective outcome of the galectin-3-T antigen/MUC1 interaction on cancer cell adhesion give explanations at the molecular level for many late clinical and experimental studies related to metastasis; e.g., the correlation between increased apical MUC1 cell surface polarization and increased lymphatic invasion, recurrence rate, and lower overall survival in patients with breast cancers [106,127]. This evidence concerns the gene LGALS3 and breast carcinoma.