Immunohistochemistry analysis of HIPK2 nuclear and cytoplasmic compartmentalization performed in 67 stage I and II wtp53-carrying breast cancer patients showed that an high integrin alpha(6)beta(4) immunoreaction is correlated with HIPK2 cytoplasmic relocalization; in contrast, when tumors are integrin alpha(6)beta(4) negative, HIPK2 is localized in the nucleus [48]. The gene discussed is HIPK2; the disease is breast carcinoma.