Finally, in an in vitro study, the leukemogenic fusion protein CBF-β-SMMHC, which is associated with the development of acute myeloid leukemia (AML), was found to delocalize HIPK2 into filamentous structures in the cytoplasm, probably interfering with the tumor-suppressor function of HIPK2 [53]. Here, HIPK2 is linked to acute myeloid leukemia.