HIPK2 and pilocytic astrocytoma: Since elevated levels of HIPK2 have been found to be associated with malignancy of pilocytic astrocytomas [46] and cervical carcinogenesis [47], it is tempting to speculate that the dynamic control of HIPK2 abundance by O-GlcNAc modification can be exploited in the treatment of HIPK2-related disorders with the use of dietary control or metabolic drugs targeting the hexosamine biosynthetic pathway (HBP)–OGT axis.