It has been proposed that there is a link between TERT, NF-κB p65, and MYC transcriptional programs given that withdrawal of TERT, likely by impairing the binding of p65 and MYC to their target promoters, alters the expression of their related genes [23,24,29], thus suggesting that TERT works as a transcriptional amplifier in cancer. The gene discussed is MYC; the disease is cancer.