We identified that the higher pT stage, unspecified and other histologic subtype of primary melanoma (including acral lentiginous melanoma) and the systemic treatment were independent prognostic factors for RFS, but patients’ age, presence of melanoma ulceration, unspecified and other histologic subtype of melanoma and positive BRAF mutation correlated with poorer OS. Here, BRAF is linked to acral lentiginous melanoma.