Intriguingly, the expression of B-cell lymphoma-2 (Bcl-2) family members, such as Bcl-2, Bcl-2-associated x protein (Bax), and building information modelling (Bim), was altered in AD brain, which controls cell death and survival processes by regulating mitochondrial outer membrane permeabilization [13, 68]. This evidence concerns the gene BCL2L11 and Alzheimer disease.