Moreover, cholesterol loss could lead to the disorders of lipid rafts and affect membrane-mediated cell activities and signaling transduction, such as membrane-related activity, and signaling including PI3K/Akt, GSK3, mTOR, MAPK/ERK, P38 MAPK, JNK, which has been linked to AD pathogenesis [6, 46, 53, 84]. The gene discussed is MAPK8; the disease is Alzheimer disease.