VDAC1 and acute myeloid leukemia: This putative mechanism of action correlates very well with the observation that several miRNAs modulating myeloid differentiation (e.g. miR-20a, miR-106b and miR-125b) [69] or AML [70, 71] are also predicted to control VDAC1 expression [72] using mirSystem, a miRNAtarget prediction software (http://mirsystem.cgm.ntu.edu.tw/index.php) [73].