From an initial analysis on human VDAC genes and their respective pseudogenes, we noticed an interesting downregulation in AML of the VDAC1 gene, compared to its expression in normal tissue, associated with increased expression of the VDAC1P8, VDAC1P1 and VDAC1P11 pseudogenes. Here, VDAC1P8 is linked to acute myeloid leukemia.