In contrast, VDAC1P4, VDAC1P11 and, more interestingly, VDAC1P8 have an expression trend exactly opposite to that of VDAC1. In general, VDAC1P8 is under-expressed compared to healthy tissue in all tumor samples tested, with the exception of AML where it is highly overexpressed. The gene discussed is VDAC1; the disease is acute myeloid leukemia.