ESR1 and endometrium adenocarcinoma: Pathology reports showed a moderately differentiated endometrial adenocarcinoma (Fig. 3), the results of IHC were protein 53 (p53) (90% +), Ki-67 (30% +), cytokeratin 8/18 (10% +), estrogen receptor (ER) (80% +), progesteron receptor (PR) (95% +), MLH1( +), PMS2( +), MSH2( +) and MSH6( +) (Table 1).