Her father and grandmother suffered from malignant tumor at a young age, it is very likely that her patrilineal family carried the TP53 gene mutation and passed it on to the patient, she got YST accompanied by subsequent EC that is associated with LFS, these two tumors rarely occur in a patient with LFS, this case represented a new finding that extends the clinical scope of LFS; since her father and grandmother had passed away, family verification could not be performed, we confirmed the mutation as a germline heterozygous variation (Fig. 6). Here, TP53 is linked to cancer.