Since nomograms have good predictive ability for cancer prognosis[43], one was constructed in this study to predict the survival of SKCM patients at 1, 5 and 10 years, and indeed, patients with high HOPX expression had a better prognosis, which is also the same as the results of H. Ushiku[44] et al. who studied the role of HOPX in pancreatic neuroendocrine tumors. The gene discussed is HOPX; the disease is cancer.