The results showed that HOPX expression was significantly upregulated in 25, including ACC (Adrenocortical carcinoma) (p < 0.001) and BRCA (Breast invasive carcinoma) (p < 0.001) (Fig. 1A), while HOPX expression was much lower in the SKCM tumor group compared to the normal group (p < 0.001) (Fig. 1B). The gene discussed is HOPX; the disease is neoplasm.