FOXM1 and cancer: As one of the key transcription factors promoting cell proliferation and metastasis, FOXM1 is over-expressed in almost all the types of clinical cancers from the TCGA database [3, 47] and the knockout of FOXM1 in multiple mouse organs inhibits the cancer development of corresponding organs, such as liver [48], lung [49], rectum [50], and ovarian cancer [51].