In addition, FOXM1 can facilitate the nuclear import process of other cancer-related transcription factors through protein-protein interactions to boost the transcriptional activities of those transcription factors, evidenced by the findings that the nuclear importing of β-catenin or Smad3 is dependent on their interaction with FOXM1 for fully activating the classical WNT or TGF-β signaling pathway [13, 14]. The gene discussed is SMAD3; the disease is cancer.