Moreover, NOD.Cg‐PrkdcscidIl2rgtm1Sug/Jic, NOD.Cg‐PrkdcscidIl2rgtm1Wjl/SzJ and NOD.Cg‐PrkdcscidJak3tm1card are also the major tools for establishing PDX-IMs [14, 33], which is characterized by a higher degree of immunodeficiency due to the decline or complete absence of natural killer (NK) cell function [33]. The gene discussed is CTSG; the disease is immunodeficiency disease.