H19 and amyotrophic lateral sclerosis: For instance, lncRNA H19 is significantly upregulated in denervation-induced muscle atrophy, the late phrase of amyotrophic lateral sclerosis (Hitachi et al. 2020; Alessio et al. 2019), as well as in COPD patients with a low fat-free mass index and low muscle strength (Lewis et al. 2016).